Science of Synthesis (abbreviated as SoS) is a full-text online reference tool for organic chemistry synthesis methods published by the German Thieme Publishing House. It covers a wide range of synthetic methods in organic chemistry and organometallic chemistry from the early 19th century to the present day and includes over 300 e-books in the fields of chemistry and pharmacy. With this database, users can simultaneously access synthetic methods, full texts of expert reviews, experimental procedures, and precise chemical reaction pathways.