Glucose-Responsive Insulin Delivery by Microneedle-Array Patches Loaded with Hypoxia-Sensitive Vesicles

章节名称: Glucose-Responsive Insulin Delivery by Microneedle-Array Patches Loaded with Hypoxia-Sensitive Vesicles
章节作者: Jicheng Yu, Yuqi Zhang, Zhen Gu
章节序号: 17
章节页码: 251-259
著作名称: Biomedical Nanotechnology
图书作者: Sarah Hurst Petrosko, Emily S. Day
出版社: Springer
P-ISBN: 9781493983148
E-ISBN: 9781493968404
摘要: In this chapter, we describe the preparation of glucose-responsive vesicles (GRVs) and the fabrication of GRV-loaded microneedle-array patches for insulin delivery. The GRVs were formed of hypoxia-sensitive hyaluronic acid (HS-HA), the synthesis of which is presented in detail. We also describe the procedure to evaluate the in vivo efficacy of this smart patch in a mouse model of chemically induced type 1 diabetes through transcutaneous administration.
DOI: https://doi.org/10.1007/978-1-4939-6840-4_17