Teacher Information
- Name
- GU Zhen ZJU Faculty Homepage
- Department
- INTL Campus
- Research
-
Drug Delivery, Biomaterials
- Document Type
- Book Chapter
Publication
- Chapter Title
-
Glucose-Responsive Insulin Delivery by Microneedle-Array Patches Loaded with Hypoxia-Sensitive Vesicles
- Author
- Chapter
-
17
- Page
-
251-259
- Source Title
-
Biomedical Nanotechnology
- Author/Author of Source
- Publisher
-
Springer
- P-ISBN
-
9781493983148
- E-ISBN
-
9781493968404
- Abstract
-
In this chapter, we describe the preparation of glucose-responsive vesicles (GRVs) and the fabrication of GRV-loaded microneedle-array patches for insulin delivery. The GRVs were formed of hypoxia-sensitive hyaluronic acid (HS-HA), the synthesis of which is presented in detail. We also describe the procedure to evaluate the in vivo efficacy of this smart patch in a mouse model of chemically induced type 1 diabetes through transcutaneous administration.
- DOI
- https://doi.org/10.1007/978-1-4939-6840-4_17
Print & Electronic Holdings
- Database
-
Springer
- Link